Nonsteroidal Anti-inflammatory Drugs Utilization Patterns and Risk of Adverse Events due to Drug-Drug Interactions among Elderly Patients: A Study from Jordan
نویسندگان
چکیده
منابع مشابه
Antagonism of antihypertensive drug therapy by nonsteroidal anti-inflammatory drugs.
Certain nonsteroidal anti-inflammatory drugs antagonize the action of antihypertensive therapy. Indomethacin has been shown to abrogate the antihypertensive effect of beta-adrenergic receptor blockers, diuretics, converting enzyme inhibitors, and several antihypertensive drug combinations, and the accumulated evidence on piroxicam indicates that it also raises arterial pressure in treated patie...
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By the year 2020, it is predicted that more than 16% of people in the United States will be 65 years of age or older1. In Taiwan, people in that age range were more than 7% of the population in 1993 and are expected to occupy 10% of the population by 2011 and 20% by 2030. Not unusually, older individuals have a number of diseases such as cardiovascular disorders and arthritis that are treated w...
متن کاملTraditional Nonsteroidal Anti-Inflammatory Drugs and Postmenopausal Hormone Therapy: A Drug–Drug Interaction?
BACKGROUND Suppression of prostacyclin (PGI2) is implicated in the cardiovascular hazard from inhibitors of cyclooxygenase (COX)-2. Furthermore, estrogen confers atheroprotection via COX-2-dependent PGI2 in mice, raising the possibility that COX inhibitors may undermine the cardioprotection, suggested by observational studies, of endogenous or exogenous estrogens. METHODS AND FINDINGS To iden...
متن کاملNonsteroidal anti-inflammatory drug use and breast cancer risk.
Findings from previous epidemiological studies are inconclusive, though they suggest nonsteroidal anti-inflammatory drug (NSAID) use is associated with a reduction in breast cancer risk. In addition, animal studies report that NSAIDs inhibit mammary tumor development. The association between NSAID use and breast cancer risk was evaluated using a case-control study design. Cases were a random sa...
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OBJECTIVE To examine the comparative safety of individual NSAIDs when given concomitantly with clopidogrel. METHODS We conducted a retrospective cohort study using Medicaid claims from five US states during 1999-2010, supplemented with Medicare claims for dual-enrollees. The exposure of interest was the first concomitant use of clopidogrel and one of the 10 selected NSAIDs after a 1-year base...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2020
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2020.03.001